Probe on Virus / Corona using an analogy
These questions may be helpful for research and I am sharing links that may be
useful can you share to the right team. These may not solve or give a solution but
it gives thoughts and may direct towards a solution as all of these are based on
probing and analogy.
BATS
Is there any relation between food, cortisol, and bats immunity?
with lower food availability cortisol level may increase
So do bats show the same immunity response during that time?
Ref:
https://www.sciencedaily.com/releases/2019/02/190226112401.htm
It has been said mitotane (Lysodren) and metyrapone (Metopirone) reduces
cortisol for humans during stress. can the same be tried with bats and checked?
so in case, their cortisol level gets increased by habitat loss/ lack of
food we can check if the virus has an effect right and by giving
Lysodren shots are possible to check their immunity level returning to normal?
Are all types of bats immune to viruses or only certain species?
By any chance, any other species other than humans had a fatal
encounter with Virus? though apes are susceptible to viruses
they may have acquired immunity as they are quite close to humans.
Can their immunity help in a study in case they are not facing fatal death?
It's known fact bats are a carrier of infections but still immune to them,
can a study of how immunity of bats differs from humans help to discover a drug?
Probably the behavior pattern and food chain would have changed in
the evolution of life forms and this helped the bats to get adopted to the virus.
Do bats,Darkness,Cave and UV rays, lights have a role to play?
Useful pointers for bats research:
Bats research team video discussion useful one.They have sites with a lot of details on bats
which gets updated regularly.Please go through this video completely
(Imp discussion of scientist on the topic)
Ref :
ref2
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Virus and PH study: (VIMP)
The differential pH with blood and lungs can intimate and release the envelope ?
The pH difference regulates the movement of fluids across the other organ and to the lungs
(blood and lungs)
So once the infection happens can the application of
nanoamps or even less current could release the virus back or
destroy them in absence of an envelope, in what way lungs get affected or impacted?
What is the affinity of viruses towards oxygen and carbon dioxide?
Virus CO2 are used as a disinfectant in sewage treatment so virus affinity may be less
whereas O2 may foster the virus?
Why UV rays are not tried out on specimens
in absence of light and in the presence of light with oxygen.
To know if it spreads in night or day faster?
Bio-electron laser be used? to resolve the above query?
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How does corona differ from Adenovirus? Can't the same drug therapy be used?
Vaccine handles meant at Hemoglobin and Antibody.
Target Cilia, Epithelial Cells:
To Be Explored: Weak ammonia solutions in treating Virus (VIMP)
Ciliogenesis:
Cilia, diabetics, obesity, smoking - how cilia can be improved?
can the improvement of Cilia help?
Improve cilia in cancer cells:
For a selection of compounds (Clofibrate, Gefitinib, Sirolimus,
Imexon and Dexamethasone) their ability to restore ciliogenesis
was confirmed in a panel of human cancer cell line models representing
different cancer types (pancreas, lung, kidney, breast).
3. Role of CD4, oxytocin (kids immune) can a
vaccine-based oxytocin help?
Most of the virus needs calcium by any chance the regulation of
the calcium controls the Corona-Virus activity?
Oxytocin can increase the calcium in muscle and helps
in performing labor activity and has proved useful in reducing stress as well.
Does oxytocin based chemical be a remedy?
https://www.creative-diagnostics.com/oxytocin-signaling-pathway.htm
https://www.zmescience.com/science/viruses-attack-oxtr-pathway/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947469/
Oxytocin and Lungs study:
https://www.nature.com/articles/s41598-019-54739-1
There is the first report of infant and mother
being infected in London. But I feel this could be a case of diabetic patients.
And oxytocin has been effective in insulin secretion,
so the inverse is true. https://diabetes.diabetesjournals.org/content/66/2/256
research paper relevant to calcium, oxytocin, and virus, sharing the same.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449087/
https://www.ncbi.nlm.nih.gov/pubmed/20684239
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433165/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512838/
https://www.medicinenet.com/oxytocin-injectable/article.htm
https://www.creative-diagnostics.com/oxytocin-signaling-pathway.htm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637930/
https://link.springer.com/referenceworkentry/10.1007/978-1-4614-1533-6_58
Does vaccine + immunity boost
(part of virus and immunity inc with oxytocin or other medicine ) help?
Can live to attenuate vaccine from other corona be used along
with immune boost drugs.
https://www.ncbi.nlm.nih.gov/pubmed/15047802
https://www.ncbi.nlm.nih.gov/pubmed/19057874
Oxytocin as immune booster:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223438/
OXYTOCIN and ASTHMA research
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922094/
Impact of cholesterol, Gem and Lov in virus treatment:
Can cholesterol treatment help in handling corona?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571833/
Any effect on patients with this medicine (Cholosterol) helped?
https://familydoctor.org/cholesterol-lowering-medicines/
Can the virus spikes/glycoprotein get distinguished with the solubility index?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981117/
https://www.sciencedaily.com/releases/2019/11/191107160735.htm
https://www.beilstein-journals.org/bjoc/articles/8/90
In what way lungs cells differ from other organs, which makes as a target for the virus.
Our organs of other cells are immune within the body and respiratory alone
gets affected by apoptosis of the cells?
Can the asthma inhalers helps,
what is the effect of increasing the temperature of air /
inhalation https://pubmed.ncbi.nlm.nih.gov/8151855/
UV rays may be helpful not as a vaccine, but to minimize spread.
by varying wavelength
Is the spread accelerates in night, compared to day can't a UV based system
be introduced to control things?
https://www.sciencedaily.com/releases/2007/10/071030080626.htm
Does this virus affect a pregnant woman?
The kids under 5 are often take vaccinations, is any infant infected?
Does any of this vaccine help?
Is the cold climate a reason or is it humidity that spreads the disease?
Is it hydrophobic? Did it affect any marine life/people at seashore city?
The virus itself an evolved mutated one can the host infected with a bacterial
or another virus mutation make it inert? host mapping?
Unlike elders, kids remain indoors and the rodents avoid the lights.
Does this multiply in the presence or absence of sunlight/UV rays?
probability of spread in day or night?
Can the spike-based virus following a similar viral glycoprotein
vaccination be tried out? Say the vaccines of HIV can be used?
https://en.wikipedia.org/wiki/CD4 (CD4 attack mechanism by HIV)
https://www.webmd.com/hiv-aids/guide/nutrition-hiv-aids-enhancing-quality-life#1
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)62269-2/fulltext
Can the H5N1 virus vaccine be used, as there is a similarity in the symptoms:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034094/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751439/
Study of ACE2 SARS and CORONA Similarity:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1287568/
The Viral Glycoprotein in the spikes gets passed through the membrane,
but what activates/ releases the RNA who intimates
the virus that it's inside the cell?
The action of releasing the RNA and hacking the cell is
instantaneous or it takes time?
The Kids and Rats are quite active, some research shows
glycoprotein are high in diabetic patients and rats and kids with
diabetic still immune to the virus. Are the lab rats/newborn rats immune to the virus?
Does the virus get passed through the patients to the soil after
cremations and microbes and remains in an inert state?
Can the immune system of a different organ be compared with that
of the human and design a vaccine?
Cytokine Storm https://covid.yale.edu/ysm/news-article/23809/
Immune modulator
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684115/
Autism and CD4 immunity:
https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-158
Can the air be extracted once the disease is found? and use the sample to
develop an antigen/vaccine?
Given that Ape is the nearest to human, why the virus is not at best to it and rendered in active ?
21. CD4 research
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118265/
https://www.frontiersin.org/articles/10.3389/fimmu.2017.00197/full
Nanotechnology in Vaccine design:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180194/
It's known fact bats are a carrier of infections but still immune to them, can a study of how immunity of bats differs from humans help to discover a drug? Probably the behaviour pattern night dwellers and food chain would have changed in the evolution of life forms and this helped the bats to get adopted to the virus study on food consumption of immune bats can it help? Does the infection from various virus nullify the effect of COVID in bats and similar species?
Are there any other species we are aware of that are infected and have proved to be fatal? for e.g. chimpanzee and monkeys?
Is there any difference in oxytocin levels in Bats and humans, can this lead to immunity difference? In bats are female/new-borns are immune or all are immune?
Africa is sparse, though the infection rate is high, is their food habit and the environmental condition has a role to play?
Some turtles live long, does the study of their DNA help in medicine to increase the life span of humans, ref: https://www.
Do Archeology and Climate change have a role to play? many advanced civilizations became extinct due to deadly disease has such diseases got unleashed again while studying history, the virus needs a host it can be seen as an untriggered bomb without a host, has it became alive while coming in contact with air?
Ref:
https://www.facebook.com/IndSciCovid/
https://www.youtube.com/watch?v=0DJ91ZWXJiw
https://www.youtube.com/watch?v=3Uugj-zxA5E
understand vaccination https://www.youtube.com/watch?v=Atrx1P2EkiQ
https://www.youtube.com/watch?v=Atrx1P2EkiQ
https://askabiologist.asu.edu/epithelial-cells
Homemade mask:
https://www.youtube.com/watch?v=Atrx1P2EkiQ
Ranking in protection
https://www.thomasnet.com/articles/other/how-surgical-masks-are-made/
Study on P2 vs Surgical Mask:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662657/
There's a significant concept that should be explained: how viruses infect cells. The spike proteins on the envelope surface of all viruses act like a key to a host cellular receptor, in this case ACE2. Not all human cells or organs have ACE2 receptor!! So only cells with this receptor (like those in the airway) can be infected. All other cells are immune because the virus essentially can't see them, which is why covid19 mostly affects the airway. The ACE2 "key" that covid19 uses to enter a cell is very specific to covid19, and it's also how our body recognizes viruses to kill them. This is what makes viruses so tricky; they all have different keys, even different strains of the same virus (e.g. flu), so immunity to one virus doesn't translate well to another -- the same goes for vaccines. Immunity/vaccines are sort of like getting a copy of the key made, which is helpful to recognize that one key, but not others. Even other coronaviruses wouldn't be similar enough, although we don't have effective vaccines for the others anyway.
ReplyDeleteTo be a bit more comprehensive, in order to get a copy of the key our body first responds to viral RNA after a cell is infected, but at that point it's too late to save the cell. So we rely on adaptive immunity (antibodies) from learning to recognize the key before the virus can even use it to infect a cell. Vaccines give us a sample key to safely learn without active infection, but e.g. an HIV vaccine can't give the key to covid19.
Calcium is a great target for host cellular processes -- it's involved in muscle contraction like you mentioned, for example. Calcium makes cells release their vesicles and secrete whatever it is they secrete (e.g. insulin), but aside from boosting cellular signaling in general, calcium/oxytocin wouldn't effect a virus.
Viruses need a host to survive and multiply. That's why they don't survive long on surfaces (moisture protects them from some damage which is why they can survive for a time), and I'd expect natural bodies of water would be too harsh an environment for the virus to survive despite all that moisture -- varying pH and different chemicals will break down the envelope before the RNA can get into a host and multiply. Same goes for soil; if there is no available host then the virus will die, and that key it uses is so specific it can only recognize the human ACE2 receptor. This is why viruses usually only affect one species, why you can't give covid19 to your pet cat. Once a patient is dead, the virus will run out of live cells to infect and live in, and it too will die by the time the body is in the ground.
I don't think I answered everything, but I hope this helps give a clearer picture of how viruses work!
Thanks
Deletethank you
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